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Am J Physiol Gastrointest Liver Physiol 295: G654-G663, 2008. First published August 14, 2008; doi:10.1152/ajpgi.90213.2008
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LIVER AND BILIARY TRACT

High dietary inorganic phosphate enhances cap-dependent protein translation, cell-cycle progression, and angiogenesis in the livers of young mice

Cheng-Xiong Xu,1 Hua Jin,6 Hwang-Tae Lim,1 Ji-Eun Kim,1,2 Ji-Young Shin,1 Eun-Sun Lee,1 Youn-Sun Chung,1 Yeon-Sook Lee,3 George Beck, Jr,4 Kee Ho Lee,5 and Myung-Haing Cho1,2,7

1Laboratory of Toxicology, College of Veterinary Medicine, 2Nano Systems Institute-National Core Research Center, 3Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea; 4Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, Georgia; 5Laboratory of Radiation Molecular Oncology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea; 6Center for Developmental Pharmacology and Toxicology, Seattle Children's Hospital Research Institute, Seattle, Washington; and 7National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea

Submitted 26 February 2008 ; accepted in final form 11 August 2008

Inorganic phosphate (Pi) plays a key role in diverse physiological functions. Recent studies have indicated that Pi affects Akt signaling through the sodium-dependent phosphate cotransporter. Akt signaling, in turn, plays an important role in liver development; however, the effects of high dietary Pi on the liver have not been investigated. Here, we examined the effects of high dietary phosphate on the liver in developing mice. We found that high dietary Pi increased liver mass through enhancing Akt-related cap-dependent protein translation, cell cycle progression, and angiogenesis. Thus careful regulation of Pi consumption may be important in maintaining normal development of the liver.

Akt; liver development


Address for reprint requests and other correspondence: M.-H. Cho, Lab. of Toxicology, Coll. of Veterinary Med., Seoul National Univ., Seoul 151-742, Korea (e-mail: mchotox{at}snu.ac.kr)






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