The diagnosis and treatment of liver disease remains a major health concern worldwide due to its diverse etiologies. New therapeutic targets are greatly needed to halt disease progression. Upon initiation of liver injury by viral infection, autoimmune disease or toxin, hepatitis and/or cholangitis may develop which can progress to cirrhosis, hepatocellular carcinoma, cholangiocarcinoma, liver failure or death. Lin28 is a stem cell marker vital for maintaining a stem cell phenotype. Inhibition of Lin28 induces cellular differentiation, whereas overexpression of Lin28 promotes cell transformation to a stem cell phenotype. Lin28 has not been extensively studied in the liver despite its capability of inducing tissue regeneration via reprogramming of oxidative enzymes in other tissues and its involvement with numerous upstream regulators and downstream targets. Theoretically, overexpression of Lin28 in certain forms of liver disease could be a potential treatment that aids in liver regeneration. Alternatively, Lin28 has been implicated numerous times in the progression of several types of cancer and is associated with increased severity of disease. In this case, Lin28 could be a potential inhibitory target to prevent malignant transformation in the liver. This review aims to explore the role of Lin28 in liver disease.
- hepatocellular carcinoma
- liver repair
- Copyright © 2016, American Journal of Physiology- Gastrointestinal and Liver Physiology