Reactive oxidative species are implicated in physiological signaling and cell fate decisions. In chronic liver diseases persistent and increased production of oxidative radicals drives a fibrogenic response that is a common feature of disease progression. Despite our understanding the biology of the main pro-oxidant enzymes, their targets and anti-oxidant mechanisms in the liver there is still lack of knowledge concerning their precise role in the pathogenesis of fibrosis. This review will examine the role of physiological redox signaling in the liver, provide an overview on recent advances in pro-oxidant and anti-oxidant pathways that are dysregulated during fibrosis, and highlight possible novel treatment targets.
- liver fibrosis
- stellate cell activation
- redox signaling
- oxidative stress
- Copyright © 2016, American Journal of Physiology-Gastrointestinal and Liver Physiology