THEMES:

Hartmut Jaeschke

Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions
Am J Physiol Gastrointest Liver Physiol 290: G1083-G1088, 2006; doi:10.1152/ajpgi.00568.2005 [Abstract] [Full Text] [PDF]  

MUCOSAL BIOLOGY:

Sandra Zoghbi, Aurélien Trompette, Jean Claustre, Mahmoud El Homsi, Javier Garzón, Gérard Jourdan, Jean-Yves Scoazec, and Pascale Plaisancié

-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a µ-opioid pathway
Am J Physiol Gastrointest Liver Physiol 290: G1105-G1113, 2006. First published December 15, 2005; doi:10.1152/ajpgi.00455.2005 [Abstract] [Full Text] [PDF]  

Adel H. Saad, Chikao Shimamoto, Takashi Nakahari, Shoko Fujiwara, Ken-ichi Katsu, and Yoshinori Marunaka

cGMP modulation of ACh-stimulated exocytosis in guinea pig antral mucous cells
Am J Physiol Gastrointest Liver Physiol 290: G1138-G1148, 2006. First published January 19, 2006; doi:10.1152/ajpgi.00357.2005 [Abstract] [Full Text] [PDF]  

Tetyana Khomenko, Sandor Szabo, Xiaoming Deng, Martin R. Jadus, Hideki Ishikawa, Klara Osapay, Zsuzsa Sandor, and Longchuan Chen

Suppression of early growth response factor-1 with egr-1 antisense oligodeoxynucleotide aggravates experimental duodenal ulcers
Am J Physiol Gastrointest Liver Physiol 290: G1211-G1218, 2006. First published February 16, 2006; doi:10.1152/ajpgi.00078.2005 [Abstract] [Full Text] [PDF]  

Adel Driss, Laetitia Charrier, Yutao Yan, Vivienne Nduati, Shanthi Sitaraman, and Didier Merlin

Dystroglycan receptor is involved in integrin activation in intestinal epithelia
Am J Physiol Gastrointest Liver Physiol 290: G1228-G1242, 2006. First published December 15, 2005; doi:10.1152/ajpgi.00378.2005 [Abstract] [Full Text] [PDF]  

Kazuhiro Nagata, Ken Wada, Atsushi Tatsuguchi, Seiji Futagami, Katya Gudis, Kazumasa Miyake, Taku Tsukui, and Choitsu Sakamoto

Heregulin- and heregulin- expression is linked to a COX-2-PGE₂ pathway in human gastric fibroblasts
Am J Physiol Gastrointest Liver Physiol 290: G1243-G1251, 2006. First published December 15, 2005; doi:10.1152/ajpgi.00253.2005 [Abstract] [Full Text] [PDF]  

Yuzhu Tang, Elzbieta A. Swietlicki, ShuJun Jiang, Kim K. Buhman, Nicholas O. Davidson, Linda C. Burkly, Marc S. Levin, and Deborah C. Rubin

Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection
Am J Physiol Gastrointest Liver Physiol 290: G1280-G1288, 2006. First published January 26, 2006; doi:10.1152/ajpgi.00426.2005 [Abstract] [Full Text] [PDF] [Supplemental Figure]  

Roberto Mazzanti, Michela Solazzo, Ornella Fantappié, Sarah Elfering, Pietro Pantaleo, Paolo Bechi, Fabio Cianchi, Adam Ettl, and Cecilia Giulivi

Differential expression proteomics of human colon cancer
Am J Physiol Gastrointest Liver Physiol 290: G1329-G1338, 2006. First published January 26, 2006; doi:10.1152/ajpgi.00563.2005 [Abstract] [Full Text] [PDF]  

INFLAMMATION/IMMUNITY/MEDIATORS:

C. Anthoni, M. G. Laukoetter, E. Rijcken, T. Vowinkel, R. Mennigen, S. Müller, N. Senninger, J. Russell, J. Jauch, J. Bergmann, D. N. Granger, and C. F. Krieglstein

Mechanisms underlying the anti-inflammatory actions of boswellic acid derivatives in experimental colitis
Am J Physiol Gastrointest Liver Physiol 290: G1131-G1137, 2006. First published January 19, 2006; doi:10.1152/ajpgi.00562.2005 [Abstract] [Full Text] [PDF]  

Andrew T. Gewirtz, Matam Vijay-Kumar, Steven R. Brant, Richard H. Duerr, Dan L. Nicolae, and Judy H. Cho

Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease
Am J Physiol Gastrointest Liver Physiol 290: G1157-G1163, 2006. First published January 26, 2006; doi:10.1152/ajpgi.00544.2005 [Abstract] [Full Text] [PDF]  

Thomas Petnehazy, Dianne Cooper, Karen Y. Stokes, Janice Russell, Katherine C. Wood, and D. Neil Granger

Angiotensin II type 1 receptors and the intestinal microvascular dysfunction induced by ischemia and reperfusion
Am J Physiol Gastrointest Liver Physiol 290: G1203-G1210, 2006. First published February 9, 2006; doi:10.1152/ajpgi.00578.2005 [Abstract] [Full Text] [PDF]  

Allan Tsung, Michael T. Stang, Atsushi Ikeda, Nathan D. Critchlow, Kunihiko Izuishi, Atsunori Nakao, Meagan H. Chan, Geetha Jeyabalan, John H. Yim, and David A. Geller

The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury
Am J Physiol Gastrointest Liver Physiol 290: G1261-G1268, 2006. First published January 12, 2006; doi:10.1152/ajpgi.00460.2005 [Abstract] [Full Text] [PDF]  

Herbert C. Yohe, Kimberley A. O'Hara, Jane A. Hunt, Tamar J. Kitzmiller, Sheryl G. Wood, Jenna L. Bement, William J. Bement, Juliana G. Szakacs, Steven A. Wrighton, Judith M. Jacobs, Vsevolod Kostrubsky, Peter R. Sinclair, and Jacqueline F. Sinclair

Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity
Am J Physiol Gastrointest Liver Physiol 290: G1269-G1279, 2006. First published January 26, 2006; doi:10.1152/ajpgi.00239.2005 [Abstract] [Full Text] [PDF]  

Anne Barbara Tietz, Antje Malo, Joachim Diebold, Alexey Kotlyarov, Andreas Herbst, Frank T. Kolligs, Barbara Brandt-Nedelev, Walter Halangk, Matthias Gaestel, Burkhard Göke, and Claus Schäfer

Gene deletion of MK2 inhibits TNF- and IL-6 and protects against cerulein-induced pancreatitis
Am J Physiol Gastrointest Liver Physiol 290: G1298-G1306, 2006. First published January 19, 2006; doi:10.1152/ajpgi.00530.2005 [Abstract] [Full Text] [PDF]  

Fuyumi Isayama, Ian N. Hines, Michael Kremer, Richard J. Milton, Christy L. Byrd, Ashley W. Perry, Stephen E. McKim, Christopher Parsons, Richard A. Rippe, and Michael D. Wheeler

LPS signaling enhances hepatic fibrogenesis caused by experimental cholestasis in mice
Am J Physiol Gastrointest Liver Physiol 290: G1318-G1328, 2006. First published January 26, 2006; doi:10.1152/ajpgi.00405.2005 [Abstract] [Full Text] [PDF]  

HORMONES AND SIGNALING:

Wandong Ai, Ying Liu, and Timothy C. Wang

Yin yang 1 (YY1) represses histidine decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site
Am J Physiol Gastrointest Liver Physiol 290: G1096-G1104, 2006. First published December 15, 2005; doi:10.1152/ajpgi.00199.2005 [Abstract] [Full Text] [PDF]  

Florian Grahammer, Guido Henke, Ciprian Sandu, Rexhep Rexhepaj, Azeemudeen Hussain, Björn Friedrich, Teut Risler, Marco Metzger, Lothar Just, Thomas Skutella, Peer Wulff, Dietmar Kuhl, and Florian Lang

Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1
Am J Physiol Gastrointest Liver Physiol 290: G1114-G1123, 2006. First published January 12, 2006; doi:10.1152/ajpgi.00231.2005 [Abstract] [Full Text] [PDF]  

Eduardo Ansorena, Carmen Berasain, María J. López Zabalza, Matías A. Ávila, Elena R. García-Trevijano, and María J. Iraburu

Differential regulation of the JNK/AP-1 pathway by S-adenosylmethionine and methylthioadenosine in primary rat hepatocytes versus HuH7 hepatoma cells
Am J Physiol Gastrointest Liver Physiol 290: G1186-G1193, 2006. First published February 9, 2006; doi:10.1152/ajpgi.00282.2005 [Abstract] [Full Text] [PDF]  

John F. Kuemmerle

Occupation of _v3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle
Am J Physiol Gastrointest Liver Physiol 290: G1194-G1202, 2006. First published September 29, 2005; doi:10.1152/ajpgi.00345.2005 [Abstract] [Full Text] [PDF]  

R. Bisschops, P. Vanden Berghe, G. Sarnelli, J. Janssens, and J. Tack

CRF-induced calcium signaling in guinea pig small intestine myenteric neurons involves CRF-1 receptors and activation of voltage-sensitive calcium channels
Am J Physiol Gastrointest Liver Physiol 290: G1252-G1260, 2006. First published December 29, 2005; doi:10.1152/ajpgi.00349.2004 [Abstract] [Full Text] [PDF]  

Galina Burdyga, Andrea Varro, Rod Dimaline, David G. Thompson, and Graham J. Dockray

Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance
Am J Physiol Gastrointest Liver Physiol 290: G1289-G1297, 2006. First published January 19, 2006; doi:10.1152/ajpgi.00543.2005 [Abstract] [Full Text] [PDF]  

NEUROREGULATION AND MOTILITY:

Mark Pimentel, Henry C. Lin, Pedram Enayati, Brian van den Burg, Hyo-Rang Lee, Jin H. Chen, Sandy Park, Yuthana Kong, and Jeffrey Conklin

Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity
Am J Physiol Gastrointest Liver Physiol 290: G1089-G1095, 2006. First published November 17, 2005; doi:10.1152/ajpgi.00574.2004 [Abstract] [Full Text] [PDF]  

Neelesh A. Tipnis, Jianmin Liu, James L. Puckett, and Ravinder K. Mittal

Common cavity pressure during gastroesophageal reflux: reassessment using simultaneous pressure, impedance, and ultrasound imaging
Am J Physiol Gastrointest Liver Physiol 290: G1149-G1156, 2006. First published January 26, 2006; doi:10.1152/ajpgi.00361.2005 [Abstract] [Full Text] [PDF]  

Adil E. Bharucha, Andrew J. Croak, John B. Gebhart, Lawrence J. Berglund, Barbara M. Seide, Alan R. Zinsmeister, and Kai-Nan An

Comparison of rectoanal axial forces in health and functional defecatory disorders
Am J Physiol Gastrointest Liver Physiol 290: G1164-G1169, 2006. First published February 2, 2006; doi:10.1152/ajpgi.00487.2005 [Abstract] [Full Text] [PDF]  

Mira Wouters, Ann De Laet, Luc Ver Donck, Eric Delpire, Pierre-Paul van Bogaert, Jean-Pierre Timmermans, Alban de Kerchove d'Exaerde, Karine Smans, and Jean-Marie Vanderwinden

Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker
Am J Physiol Gastrointest Liver Physiol 290: G1219-G1227, 2006. First published August 25, 2005; doi:10.1152/ajpgi.00032.2005 [Abstract] [Full Text] [PDF]  

Ling Cheng, Weibiao Cao, Claudio Fiocchi, Jose Behar, Piero Biancani, and Karen M. Harnett

HCl-induced inflammatory mediators in cat esophageal mucosa and inflammatory mediators in esophageal circular muscle in an in vitro model of esophagitis
Am J Physiol Gastrointest Liver Physiol 290: G1307-G1317, 2006. First published January 26, 2006; doi:10.1152/ajpgi.00576.2005 [Abstract] [Full Text] [PDF]  

LIVER AND BILIARY TRACT:

James L. Boyer, Michael Trauner, Albert Mennone, Carol J. Soroka, Shi-Ying Cai, Tarek Moustafa, Gernot Zollner, Jin Young Lee, and Nazzareno Ballatori

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OST-OST in cholestasis in humans and rodents
Am J Physiol Gastrointest Liver Physiol 290: G1124-G1130, 2006. First published January 19, 2006; doi:10.1152/ajpgi.00539.2005 [Abstract] [Full Text] [PDF]  

Xiaobo Lin, Zhouji Chen, Pin Yue, Maurizio R. Averna, Richard E. Ostlund, Jr., Mark A. Watson, and Gustav Schonfeld

A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation
Am J Physiol Gastrointest Liver Physiol 290: G1170-G1176, 2006. First published February 2, 2006; doi:10.1152/ajpgi.00402.2005 [Abstract] [Full Text] [PDF]  

Anniek Werner, Rick Havinga, Frank Perton, Folkert Kuipers, and Henkjan J. Verkade

Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice
Am J Physiol Gastrointest Liver Physiol 290: G1177-G1185, 2006. First published December 29, 2005; doi:10.1152/ajpgi.00127.2005 [Abstract] [Full Text] [PDF]  

Ariel E. Feldstein, Nathan W. Werneburg, ZhengZheng Li, Steven F. Bronk, and Gregory J. Gores

Bax inhibition protects against free fatty acid-induced lysosomal permeabilization
Am J Physiol Gastrointest Liver Physiol 290: G1339-G1346, 2006. First published February 16, 2006; doi:10.1152/ajpgi.00509.2005 [Abstract] [Full Text] [PDF]  

REPORTS:

Ying Li, Xiaoyin Wu, Ying Zhao, Shengliang Chen, and Chung Owyang

Ghrelin acts on the dorsal vagal complex to stimulate pancreatic protein secretion
Am J Physiol Gastrointest Liver Physiol 290: G1350-G1358, 2006. First published February 9, 2006; doi:10.1152/ajpgi.00493.2005 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

J. D. Huizinga, C. M. McKay, E. J. White, W. J. E. P. Lammers, T. C. Seerden, J. G. De Man, B. Y. De Winter, and P. A. Pelckmans

The Many Facets of Intestinal Peristalsis
Am J Physiol Gastrointest Liver Physiol 290: G1347-G1349, 2006; doi:10.1152/ajpgi.00060.2006 [Full Text] [PDF]  

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