Table 1.

Plasma AST, ALT, AP, and cholesterol

Week 0Week 4 (=1 wk after BDL) Week 7 (=4 wk after BDL)
PL TG EFAD PL TG EFAD PL TG EFAD
AST, U/I 48±30 659±323* 549±23 451±116 739±288
ALT, U/I 34±14 354±199* 261±82 253±60 406±192
AP, U/I 81±31 895±228* 1,885±1,097† 1,520±278† 1,167±385
Cholesterol, mM 3.2±1.2 3.3±1.7 9.2±2.8‡ 9.4±0.5‡ 6.4±2.7§
  • Data represent means ± SD of 4—6 mice/group. EFAD, essential fatty acid deficiency. Plasma aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (AP), and cholesterol were measured at baseline (week 0), after 1 wk of bile duct ligation (BDL; week 4), and after 4 wk of BDL (week 7) in triglyceride (TG)-supplemented, phospholipid (PL)-supplemented, or nonsupplemented mice. *P < 0.001 for AST, ALT, and AP concentrations in week 4 compared with baseline. †P < 0.001 for TG- and PL-supplemented mice in week 4 vs. week 7.P < 0.01 for cholesterol levels in TG- and PL-supplemented mice in week 7 vs. week 4. §P < 0.005 for cholesterol levels in EFAD vs. TG- and PL-supplemented mice in week 7.