Table 1.

Effects of 5-HTP on fecal scores in mice

Fecal Scores in 15 minFecal Scores in 90 min
Number of miceNumber of fecal pelletsFecal output, mg wet wtWater content, %Number of fecal pelletsFecal output, mg wet wtWater content, %
Vehicle60.8±0.719±1349.9±4.33.3±0.7106±2857.8±2.3
5-HTP
    0.5 mg/kg56.0±0.6*223±21*77.5±1.0*10.8±1.4*339±37*76.1±0.5*
    1 mg/kg69.3±1.7*316±52*70.0±3.0*10.3±1.8*337±53*69.2±3.1*
    5 mg/kg69.8±0.7*412±29*74.3±3.2*12.8±1.0*486±28*74.5±2.6*
    10 mg/kg68.0±1.6*261±76*73.6±3.1*10.8±1.1*335±55*71.6±3.0*
  • Data represent means ± SE of fecal scores at 15 min and cumulative scores for the 90-min experimental time. Vehicle or 5-hydroxytryptophan (5-HTP) was administered intraperitoneally, and the fecal output was determined at 15-min intervals for the following 90 min.

  • * P<0.05 vs. vehicle.