Table 1.

Contribution of trans fats and high-fructose corn syrup to morphological, biochemical, and histological abnormalities of the ALIOS model at 16 wk

ControlALIOSALIOS Minus Trans FatsALIOS Minus HFCS
Weight, g27.7±2.9a39.2±2.5b37.3±2.6b,c35.6±3.4c
Liver weight, g0.91±0.08a1.67±0.23b1.19±0.09c1.41±0.29d
Liver triglyceride, mg/g43±9a123±72b69±25a,b100±53b
ALT, U/l31±6a83±34b41±15a83±32b
Plasma cholesterol, mg/dl80±6a143±12b136±19b138±21b
Plasma triglycerides59±8a70±12a106±14b66±17a
GTT AUC2,098±632a1,876±234a1,709±461a
GTT glucose at 80 min, mM15.2±4.1a14.9±3.6a11.2±1.8b
  • Variance statistic is SD. Glucose tolerance testing (GTT) was not performed on control mice at the same time as the other 3 treatment groups. ALIOS, American Lifestyle-Induced Obesity Syndrome; HFCS, high-fructose corn syrup; ALT, alanine aminotransferase; AUC, area under the curve. Superscript letters denote significant differences among the treatment groups (i.e., there is no difference among values annotated with the same letter), P < 0.05 by ANOVA.