Table 4.

List of miRNAs differentially expressed in whole colons of AOM/DSS- or DSS-treated mice and in human IBD

miRNAAOM/DSS Mouse ModelHuman IBDReference
miR-29cupactive CDup19
inactive CD
miR-106aupactive CDup65
active CD19
inactive CD
miR-140*upactive CDup33
miR-146aupactive CDup19
miR-146binactive CD
miR-150upactive CDup19
inactive CD
active UC8
inactive UCdown19
miR-196bupinactive UCdown19
active UC33
active CDup9
miR-223upactive CDup65
active UC19
inactive CD
inactive UCdown19
miR-328-5pupactive CDdown33
miR-375upactive UCup19
active CDdown65
miRNADSS Mouse ModelHuman IBD
miR-21upactive UCup65
active UC60
active CD65
active CD19
inactive CD19
miR-133bdownactive CDup19
inactive CD19
miR-143downactive UCdown53
miR-145
miR-146aupactive CDup19
inactive CD
miR-146b
miR-150upactive CDup19
inactive CD
active UC8
inactive UCdown19
miR-223upactive CDup65
active UC19
inactive CD
inactive UCdown19
  • IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn's disease.

  • Only mouse colon miRNA significantly modified by the AOM/DSS or DSS treatment (P < 0.05, see Table 1 and 2, respectively) are considered for comparison.

  • * miRNA star.